Drug interactions
Itraconazole + Vorinostat
Severity: Moderate
Itraconazole and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT prolongation, so combined use may add to the risk of arrhythmia, including torsades de pointes. The risk is greater with electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Itraconazole and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Vorinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization (QTc).
What to do
Check baseline and periodic ECGs and correct potassium and magnesium before and during combined therapy. Consider an alternative antifungal in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Itraconazole with Vorinostat?
MediHelp rates the interaction as moderate. Itraconazole and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QT prolongation, so combined use may add to the risk of arrhythmia, including torsades de pointes. The risk is greater with electrolyte disturbances or underlying heart disease.
How serious is the interaction between Itraconazole and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and periodic ECGs and correct potassium and magnesium before and during combined therapy. Consider an alternative antifungal in patients with other QT risk factors.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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