Drug interactions
Ivacaftor + Loperamide
Severity: Minor
Ivacaftor and Loperamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its metabolite weakly inhibit P-glycoprotein and may modestly increase exposure to loperamide. The clinical effect is usually small at labeled loperamide doses.
What this interaction means in plain words
Ivacaftor and Loperamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Weak P-gp inhibition by ivacaftor reduces loperamide efflux.
What to do
Use labeled loperamide doses and monitor for excessive constipation or CNS effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loperamide
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Loperamide?
MediHelp rates the interaction as minor. Ivacaftor and Loperamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor and its metabolite weakly inhibit P-glycoprotein and may modestly increase exposure to loperamide. The clinical effect is usually small at labeled loperamide doses.
How serious is the interaction between Ivacaftor and Loperamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use labeled loperamide doses and monitor for excessive constipation or CNS effects.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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