Drug interactions
Ivacaftor + Mefloquine
Severity: Moderate
Ivacaftor and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor weakly inhibits P-glycoprotein and may increase exposure to mefloquine, a P-gp substrate. This may increase mefloquine adverse effects.
What this interaction means in plain words
Ivacaftor and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivacaftor belongs to Miscellaneous; Mefloquine belongs to Anti Parasitic.
Why it happens
Ivacaftor inhibition of P-glycoprotein efflux increases mefloquine absorption.
What to do
Monitor for neuropsychiatric and cardiac adverse effects of mefloquine. Consider an alternative antimalarial if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Mefloquine?
MediHelp rates the interaction as moderate. Ivacaftor and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor weakly inhibits P-glycoprotein and may increase exposure to mefloquine, a P-gp substrate. This may increase mefloquine adverse effects.
How serious is the interaction between Ivacaftor and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropsychiatric and cardiac adverse effects of mefloquine. Consider an alternative antimalarial if symptoms appear.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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