Drug interactions
Mavacamten + Medroxyprogesterone
Severity: Major
Mavacamten and Medroxyprogesterone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten may lower progestin exposure through CYP induction, risking contraceptive failure or breakthrough bleeding.
What this interaction means in plain words
Mavacamten and Medroxyprogesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mavacamten belongs to Cardiovascular; Medroxyprogesterone belongs to Endocrine.
Why it happens
Mavacamten induces CYP3A4, increasing medroxyprogesterone metabolism.
What to do
Use a contraceptive method unaffected by enzyme induction, such as an intrauterine system, or add a barrier method during therapy and for 4 months after the last mavacamten dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Medroxyprogesterone
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Medroxyprogesterone?
MediHelp rates the interaction as major. Mavacamten and Medroxyprogesterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten may lower progestin exposure through CYP induction, risking contraceptive failure or breakthrough bleeding.
How serious is the interaction between Mavacamten and Medroxyprogesterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a contraceptive method unaffected by enzyme induction, such as an intrauterine system, or add a barrier method during therapy and for 4 months after the last mavacamten dose.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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