Drug interactions
Ivosidenib + Montelukast
Severity: Minor
Ivosidenib and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces several CYP enzymes, which could lower montelukast concentrations. Montelukast is mainly cleared by CYP2C8, with CYP2C9 and CYP3A4 playing lesser roles, so any reduction in effect is likely modest.
What this interaction means in plain words
Ivosidenib and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivosidenib belongs to Oncology; Montelukast belongs to Respiratory.
Why it happens
Enzyme induction by ivosidenib may modestly increase montelukast metabolism.
What to do
No empirical change is needed; monitor asthma or allergy control and reassess if it worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Montelukast?
MediHelp rates the interaction as minor. Ivosidenib and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivosidenib induces several CYP enzymes, which could lower montelukast concentrations. Montelukast is mainly cleared by CYP2C8, with CYP2C9 and CYP3A4 playing lesser roles, so any reduction in effect is likely modest.
How serious is the interaction between Ivosidenib and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical change is needed; monitor asthma or allergy control and reassess if it worsens.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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