Drug interactions
Ivosidenib + Progesterone
Severity: Moderate
Ivosidenib and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower progesterone exposure, reducing its efficacy. This is relevant for hormonal contraception and replacement.
What this interaction means in plain words
Ivosidenib and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Progesterone belongs to Endocrine.
Why it happens
CYP3A4 induction by ivosidenib increases progesterone metabolism.
What to do
Use an additional or alternative non-hormonal contraceptive method. Monitor for loss of progesterone effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Progesterone?
MediHelp rates the interaction as moderate. Ivosidenib and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower progesterone exposure, reducing its efficacy. This is relevant for hormonal contraception and replacement.
How serious is the interaction between Ivosidenib and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional or alternative non-hormonal contraceptive method. Monitor for loss of progesterone effect.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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