Drug interactions
Ivosidenib + Ticlopidine
Severity: Moderate
Ivosidenib and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is a CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Ticlopidine is partly metabolized by CYP3A4, but its clinical effect depends on a complex activation pathway, so the net effect is uncertain. Reduced antiplatelet effect is possible.
What this interaction means in plain words
Ivosidenib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Ticlopidine belongs to Cardiovascular.
Why it happens
Ivosidenib induces CYP3A4, potentially increasing the metabolism of ticlopidine.
What to do
Consider an alternative antiplatelet agent if ticlopidine is needed for stent protection. If coadministered, monitor for signs of reduced antiplatelet efficacy and thrombotic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Ticlopidine?
MediHelp rates the interaction as moderate. Ivosidenib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib is a CYP3A4 inducer and may lower exposure to CYP3A4 substrates. Ticlopidine is partly metabolized by CYP3A4, but its clinical effect depends on a complex activation pathway, so the net effect is uncertain. Reduced antiplatelet effect is possible.
How serious is the interaction between Ivosidenib and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiplatelet agent if ticlopidine is needed for stent protection. If coadministered, monitor for signs of reduced antiplatelet efficacy and thrombotic events.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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