Drug interactions
Ivosidenib + Vilazodone
Severity: Moderate
Ivosidenib and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower vilazodone concentrations, which could reduce antidepressant effect. Ivosidenib can also prolong the QT interval, but this is not specific to vilazodone.
What this interaction means in plain words
Ivosidenib and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Vilazodone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increasing the metabolism of vilazodone.
What to do
Monitor for worsening depressive symptoms and consider vilazodone dose adjustment according to response. Reassess the dose when ivosidenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Vilazodone?
MediHelp rates the interaction as moderate. Ivosidenib and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower vilazodone concentrations, which could reduce antidepressant effect. Ivosidenib can also prolong the QT interval, but this is not specific to vilazodone.
How serious is the interaction between Ivosidenib and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening depressive symptoms and consider vilazodone dose adjustment according to response. Reassess the dose when ivosidenib is stopped.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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