Drug interactions
Ixazomib + Lenacapavir
Severity: Minor
Ixazomib and Lenacapavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor with a very long half-life after subcutaneous dosing. Ixazomib exposure may rise modestly, but it is not heavily dependent on CYP3A.
What this interaction means in plain words
Ixazomib and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixazomib belongs to Oncology; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, which may modestly reduce ixazomib metabolism.
What to do
No empirical dose change is needed; monitor for ixazomib adverse effects, including after lenacapavir has been stopped given its prolonged exposure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Ixazomib with Lenacapavir?
MediHelp rates the interaction as minor. Ixazomib and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A inhibitor with a very long half-life after subcutaneous dosing. Ixazomib exposure may rise modestly, but it is not heavily dependent on CYP3A.
How serious is the interaction between Ixazomib and Lenacapavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for ixazomib adverse effects, including after lenacapavir has been stopped given its prolonged exposure.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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