Drug interactions
Ixazomib + Mitotane
Severity: Major
Ixazomib and Mitotane: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a potent CYP3A4 inducer with a very long duration of effect. It can markedly reduce ixazomib exposure and cause loss of efficacy, even after mitotane is stopped.
What this interaction means in plain words
Ixazomib and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ixazomib belongs to Oncology; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, accelerating ixazomib metabolism.
What to do
Avoid concomitant use; the induction persists for weeks after mitotane discontinuation. If unavoidable, monitor disease response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Ixazomib with Mitotane?
MediHelp rates the interaction as major. Ixazomib and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a potent CYP3A4 inducer with a very long duration of effect. It can markedly reduce ixazomib exposure and cause loss of efficacy, even after mitotane is stopped.
How serious is the interaction between Ixazomib and Mitotane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; the induction persists for weeks after mitotane discontinuation. If unavoidable, monitor disease response closely.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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