Drug interactions
Ketoconazole + Medroxyprogesterone
Severity: Minor
Ketoconazole and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may increase medroxyprogesterone concentrations, potentially increasing progestogenic adverse effects such as fluid retention, mood change or breakthrough bleeding changes. The clinical impact is generally modest.
What this interaction means in plain words
Ketoconazole and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoconazole belongs to Anti Fungals; Medroxyprogesterone belongs to Endocrine.
Why it happens
Ketoconazole inhibits CYP3A4, which metabolizes medroxyprogesterone.
What to do
No empirical dose change is needed; monitor for increased progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Ketoconazole with Medroxyprogesterone?
MediHelp rates the interaction as minor. Ketoconazole and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may increase medroxyprogesterone concentrations, potentially increasing progestogenic adverse effects such as fluid retention, mood change or breakthrough bleeding changes. The clinical impact is generally modest.
How serious is the interaction between Ketoconazole and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for increased progestogenic adverse effects.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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