Drug interactions
Ketoconazole + Progesterone
Severity: Moderate
Ketoconazole and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole strongly inhibits CYP3A4 and may increase progesterone exposure, especially after oral dosing. This may intensify side effects such as drowsiness and dizziness.
What this interaction means in plain words
Ketoconazole and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Progesterone belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition reduces progesterone metabolism.
What to do
Monitor for excess progestogenic effects and reduce the progesterone dose if needed, or use a non-oral route.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Progesterone?
MediHelp rates the interaction as moderate. Ketoconazole and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole strongly inhibits CYP3A4 and may increase progesterone exposure, especially after oral dosing. This may intensify side effects such as drowsiness and dizziness.
How serious is the interaction between Ketoconazole and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess progestogenic effects and reduce the progesterone dose if needed, or use a non-oral route.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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