Drug interactions
Ketoconazole + Sodium zirconium cyclosilicate
Severity: Moderate
Ketoconazole and Sodium zirconium cyclosilicate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole requires an acidic stomach for dissolution, and sodium zirconium cyclosilicate transiently raises gastric pH. This may reduce ketoconazole absorption and antifungal efficacy.
What this interaction means in plain words
Ketoconazole and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH decreases dissolution and absorption of ketoconazole.
What to do
Give ketoconazole at least 2 hours before or after sodium zirconium cyclosilicate and monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Ketoconazole with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as moderate. Ketoconazole and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole requires an acidic stomach for dissolution, and sodium zirconium cyclosilicate transiently raises gastric pH. This may reduce ketoconazole absorption and antifungal efficacy.
How serious is the interaction between Ketoconazole and Sodium zirconium cyclosilicate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give ketoconazole at least 2 hours before or after sodium zirconium cyclosilicate and monitor clinical response.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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