Drug interactions
Ketoconazole + Sucralfate
Severity: Moderate
Ketoconazole and Sucralfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole needs gastric acidity for dissolution and absorption. Sucralfate may reduce ketoconazole absorption by binding it and by raising gastric pH, which risks reduced antifungal efficacy.
What this interaction means in plain words
Ketoconazole and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Reduced oral absorption through binding in the gut and increased gastric pH, which impairs ketoconazole dissolution.
What to do
Separate ketoconazole from sucralfate by at least 2 hours, giving ketoconazole first. Monitor antifungal response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sucralfate
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Sucralfate?
MediHelp rates the interaction as moderate. Ketoconazole and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole needs gastric acidity for dissolution and absorption. Sucralfate may reduce ketoconazole absorption by binding it and by raising gastric pH, which risks reduced antifungal efficacy.
How serious is the interaction between Ketoconazole and Sucralfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate ketoconazole from sucralfate by at least 2 hours, giving ketoconazole first. Monitor antifungal response.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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