Drug interactions
Ketoprofen + Paromomycin
Severity: Minor
Ketoprofen and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, so systemic interaction with ketoprofen is unlikely. NSAID-related reduction in aminoglycoside clearance has been described mainly with parenteral drugs in neonates.
What this interaction means in plain words
Ketoprofen and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoprofen belongs to Musculoskeletal; Paromomycin belongs to Anti Bacterial.
Why it happens
NSAID-related reduction in renal aminoglycoside clearance, relevant only with meaningful absorption.
What to do
No routine action is needed; monitor renal function if the patient has renal impairment or inflamed bowel allowing absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Ketoprofen with Paromomycin?
MediHelp rates the interaction as minor. Ketoprofen and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin is minimally absorbed, so systemic interaction with ketoprofen is unlikely. NSAID-related reduction in aminoglycoside clearance has been described mainly with parenteral drugs in neonates.
How serious is the interaction between Ketoprofen and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor renal function if the patient has renal impairment or inflamed bowel allowing absorption.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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