Drug interactions
Ketorolac intranasal + Silodosin
Severity: Minor
Ketorolac intranasal and Silodosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the effect of some antihypertensives, but silodosin is used for urinary symptoms of BPH and has little blood pressure dependence on prostaglandins. Any reduction in effect is unlikely to be clinically meaningful, and systemic exposure from intranasal ketorolac is limited.
What this interaction means in plain words
Ketorolac intranasal and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical prostaglandin inhibition opposing vasodilation; not established for silodosin.
What to do
No action is generally required. Review the response of urinary symptoms if NSAID use becomes prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Ketorolac intranasal with Silodosin?
MediHelp rates the interaction as minor. Ketorolac intranasal and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can blunt the effect of some antihypertensives, but silodosin is used for urinary symptoms of BPH and has little blood pressure dependence on prostaglandins. Any reduction in effect is unlikely to be clinically meaningful, and systemic exposure from intranasal ketorolac is limited.
How serious is the interaction between Ketorolac intranasal and Silodosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required. Review the response of urinary symptoms if NSAID use becomes prolonged.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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