Drug interactions
Labetalol + Lasmiditan
Severity: Moderate
Labetalol and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan can lower heart rate, and in a study with propranolol it produced a further drop in heart rate. Combined with labetalol, bradycardia may be more pronounced.
What this interaction means in plain words
Labetalol and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive heart rate lowering through lasmiditan's effect and beta-adrenergic blockade.
What to do
Monitor heart rate and symptoms of bradycardia, such as dizziness, after lasmiditan doses in patients on labetalol. Take extra care in patients with existing conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Labetalol with Lasmiditan?
MediHelp rates the interaction as moderate. Labetalol and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan can lower heart rate, and in a study with propranolol it produced a further drop in heart rate. Combined with labetalol, bradycardia may be more pronounced.
How serious is the interaction between Labetalol and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and symptoms of bradycardia, such as dizziness, after lasmiditan doses in patients on labetalol. Take extra care in patients with existing conduction disease.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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