Drug interactions
Labetalol + Losartan
Severity: Moderate
Labetalol and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan lowers blood pressure and can raise serum potassium, so combined use with labetalol may cause additive hypotension. Hyperkalemia is more likely in renal impairment.
What this interaction means in plain words
Labetalol and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with angiotensin receptor blockade reducing aldosterone-mediated potassium excretion.
What to do
Monitor blood pressure, serum potassium and renal function after starting or changing doses. Adjust therapy if hypotension or hyperkalemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Labetalol with Losartan?
MediHelp rates the interaction as moderate. Labetalol and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Losartan lowers blood pressure and can raise serum potassium, so combined use with labetalol may cause additive hypotension. Hyperkalemia is more likely in renal impairment.
How serious is the interaction between Labetalol and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and renal function after starting or changing doses. Adjust therapy if hypotension or hyperkalemia occurs.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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