Drug interactions
Labetalol + Lurasidone
Severity: Moderate
Labetalol and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-1 adrenergic blocking activity that can cause orthostatic hypotension, which may add to the hypotensive effect of labetalol. Dizziness, syncope and falls are possible, especially at the start of therapy.
What this interaction means in plain words
Labetalol and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic antagonism of lurasidone and the alpha/beta-blockade of labetalol.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Labetalol with Lurasidone?
MediHelp rates the interaction as moderate. Labetalol and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone has alpha-1 adrenergic blocking activity that can cause orthostatic hypotension, which may add to the hypotensive effect of labetalol. Dizziness, syncope and falls are possible, especially at the start of therapy.
How serious is the interaction between Labetalol and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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