Drug interactions
Labetalol + Mefloquine
Severity: Minor
Labetalol and Mefloquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can cause bradycardia and conduction disturbances, and labetalol also lowers heart rate and blood pressure. The combination may produce additive bradycardia, hypotension or conduction block.
What this interaction means in plain words
Labetalol and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Labetalol belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive effects on cardiac conduction; no established pharmacokinetic interaction.
What to do
Monitor heart rate and blood pressure when starting mefloquine in patients on labetalol. Reassess if symptomatic bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Mefloquine?
MediHelp rates the interaction as minor. Labetalol and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mefloquine can cause bradycardia and conduction disturbances, and labetalol also lowers heart rate and blood pressure. The combination may produce additive bradycardia, hypotension or conduction block.
How serious is the interaction between Labetalol and Mefloquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting mefloquine in patients on labetalol. Reassess if symptomatic bradycardia occurs.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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