Drug interactions
Labetalol + Nisoldipine
Severity: Moderate
Labetalol and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol and nisoldipine both lower blood pressure, so together they can cause excessive hypotension, dizziness or reflex effects. The combination is frequently used on purpose but needs careful titration.
What this interaction means in plain words
Labetalol and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effect from adrenergic blockade and dihydropyridine calcium channel blockade.
What to do
Monitor blood pressure and heart rate when initiating or adjusting either drug. Reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Labetalol with Nisoldipine?
MediHelp rates the interaction as moderate. Labetalol and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol and nisoldipine both lower blood pressure, so together they can cause excessive hypotension, dizziness or reflex effects. The combination is frequently used on purpose but needs careful titration.
How serious is the interaction between Labetalol and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when initiating or adjusting either drug. Reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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