Drug interactions
Lacosamide + Lenacapavir
Severity: Minor
Lacosamide and Lenacapavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may raise exposure to CYP3A substrates, with the effect lingering for months after subcutaneous dosing. Lacosamide is only partly metabolised by CYP3A4, so the increase is expected to be modest.
What this interaction means in plain words
Lacosamide and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lacosamide belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by lenacapavir reduces lacosamide metabolism.
What to do
Monitor for dizziness, ataxia and conduction effects, and reduce the lacosamide dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lacosamide with Lenacapavir?
MediHelp rates the interaction as minor. Lacosamide and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A inhibitor and may raise exposure to CYP3A substrates, with the effect lingering for months after subcutaneous dosing. Lacosamide is only partly metabolised by CYP3A4, so the increase is expected to be modest.
How serious is the interaction between Lacosamide and Lenacapavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, ataxia and conduction effects, and reduce the lacosamide dose if adverse effects occur.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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