Drug interactions
Lacosamide + Mifepristone
Severity: Minor
Lacosamide and Mifepristone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4, one of several enzymes that contribute to lacosamide clearance. Lacosamide exposure may rise modestly, but because other pathways (notably CYP2C19) and renal excretion also contribute, the effect is usually limited.
What this interaction means in plain words
Lacosamide and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lacosamide belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibition of CYP3A4 may slightly reduce the metabolism of lacosamide.
What to do
No routine dose change is needed; watch for dizziness, ataxia or PR-interval effects if lacosamide is being used at high doses or the patient has renal or hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Lacosamide with Mifepristone?
MediHelp rates the interaction as minor. Lacosamide and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone inhibits CYP3A4, one of several enzymes that contribute to lacosamide clearance. Lacosamide exposure may rise modestly, but because other pathways (notably CYP2C19) and renal excretion also contribute, the effect is usually limited.
How serious is the interaction between Lacosamide and Mifepristone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for dizziness, ataxia or PR-interval effects if lacosamide is being used at high doses or the patient has renal or hepatic impairment.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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