Drug interactions
Lacosamide + Nicardipine
Severity: Minor
Lacosamide and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lacosamide is cleared by several pathways, including CYP2C19, CYP3A4 and CYP2C9, and none is dominant. Nicardipine is not expected to cause a clinically meaningful increase in lacosamide levels. Both drugs can affect cardiac conduction, so PR interval effects are theoretically additive.
What this interaction means in plain words
Lacosamide and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lacosamide belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Possible weak inhibition of lacosamide metabolism by nicardipine; additive effects on cardiac conduction are theoretical.
What to do
No dose change is needed. Consider an ECG in patients with conduction disease or on other PR-prolonging drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Nicardipine?
MediHelp rates the interaction as minor. Lacosamide and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lacosamide is cleared by several pathways, including CYP2C19, CYP3A4 and CYP2C9, and none is dominant. Nicardipine is not expected to cause a clinically meaningful increase in lacosamide levels. Both drugs can affect cardiac conduction, so PR interval effects are theoretically additive.
How serious is the interaction between Lacosamide and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Consider an ECG in patients with conduction disease or on other PR-prolonging drugs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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