Drug interactions
Lacosamide + Quinidine
Severity: Moderate
Lacosamide and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine may modestly raise lacosamide levels through CYP3A4 inhibition, although lacosamide has several clearance pathways. Both drugs affect cardiac conduction, since lacosamide can prolong the PR interval and quinidine slows conduction.
What this interaction means in plain words
Lacosamide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lacosamide belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
CYP3A4 inhibition by quinidine plus additive effects on cardiac conduction.
What to do
Monitor ECG, especially PR and QT intervals, and watch for dizziness, ataxia and bradycardia. Lower the lacosamide dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Quinidine?
MediHelp rates the interaction as moderate. Lacosamide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine may modestly raise lacosamide levels through CYP3A4 inhibition, although lacosamide has several clearance pathways. Both drugs affect cardiac conduction, since lacosamide can prolong the PR interval and quinidine slows conduction.
How serious is the interaction between Lacosamide and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, especially PR and QT intervals, and watch for dizziness, ataxia and bradycardia. Lower the lacosamide dose if adverse effects appear.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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