Drug interactions
Lacosamide + Sparsentan
Severity: Minor
Lacosamide and Sparsentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan induces CYP2C9, which is a minor pathway for lacosamide. Any reduction in lacosamide levels is likely to be small.
What this interaction means in plain words
Lacosamide and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lacosamide belongs to Central Nervous System; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan may modestly induce enzymes involved in lacosamide metabolism.
What to do
No routine adjustment is needed; monitor seizure control and adjust the lacosamide dose if breakthrough seizures occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Lacosamide with Sparsentan?
MediHelp rates the interaction as minor. Lacosamide and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sparsentan induces CYP2C9, which is a minor pathway for lacosamide. Any reduction in lacosamide levels is likely to be small.
How serious is the interaction between Lacosamide and Sparsentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor seizure control and adjust the lacosamide dose if breakthrough seizures occur.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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