Drug interactions
Lanthanum carbonate + Ofloxacin
Severity: Moderate
Lanthanum carbonate and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lanthanum is a polyvalent cation that binds oral ofloxacin in the gut and lowers its absorption. This can reduce antibiotic levels enough to cause treatment failure.
What this interaction means in plain words
Lanthanum carbonate and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lanthanum carbonate belongs to Miscellaneous; Ofloxacin belongs to Anti Bacterial.
Why it happens
Chelation of ofloxacin by lanthanum cations in the gastrointestinal tract reduces oral absorption.
What to do
Give oral ofloxacin at least 2 hours before or 4 hours after lanthanum carbonate. Monitor clinical response to the antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Lanthanum carbonate
Frequently asked questions
Can I take Lanthanum carbonate with Ofloxacin?
MediHelp rates the interaction as moderate. Lanthanum carbonate and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lanthanum is a polyvalent cation that binds oral ofloxacin in the gut and lowers its absorption. This can reduce antibiotic levels enough to cause treatment failure.
How serious is the interaction between Lanthanum carbonate and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral ofloxacin at least 2 hours before or 4 hours after lanthanum carbonate. Monitor clinical response to the antibiotic.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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