Drug interactions
Lapatinib + Methylprednisolone
Severity: Moderate
Lapatinib and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and P-glycoprotein and may increase methylprednisolone exposure. This can intensify corticosteroid adverse effects such as hyperglycemia, fluid retention and immunosuppression.
What this interaction means in plain words
Lapatinib and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Methylprednisolone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux by lapatinib raises methylprednisolone concentrations.
What to do
Monitor for signs of corticosteroid excess, and reduce the methylprednisolone dose if they develop. Check blood glucose in susceptible patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Methylprednisolone?
MediHelp rates the interaction as moderate. Lapatinib and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and P-glycoprotein and may increase methylprednisolone exposure. This can intensify corticosteroid adverse effects such as hyperglycemia, fluid retention and immunosuppression.
How serious is the interaction between Lapatinib and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess, and reduce the methylprednisolone dose if they develop. Check blood glucose in susceptible patients.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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