Drug interactions
Lapatinib + Omaveloxolone
Severity: Moderate
Lapatinib and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is mainly metabolized by CYP3A4, and lapatinib may increase its exposure. This may increase adverse effects such as liver enzyme elevation.
What this interaction means in plain words
Lapatinib and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Omaveloxolone belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by lapatinib decreases omaveloxolone clearance.
What to do
If unavoidable, reduce omaveloxolone to 100 mg daily and monitor for adverse effects and liver enzymes. Reduce further to 50 mg if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Lapatinib with Omaveloxolone?
MediHelp rates the interaction as moderate. Lapatinib and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone is mainly metabolized by CYP3A4, and lapatinib may increase its exposure. This may increase adverse effects such as liver enzyme elevation.
How serious is the interaction between Lapatinib and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If unavoidable, reduce omaveloxolone to 100 mg daily and monitor for adverse effects and liver enzymes. Reduce further to 50 mg if effects emerge.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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