Drug interactions
Lapatinib + Ozanimod
Severity: Moderate
Lapatinib and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits BCRP and may raise exposure to ozanimod's active metabolites. This could increase ozanimod adverse effects such as bradycardia, hepatic effects and infection.
What this interaction means in plain words
Lapatinib and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Ozanimod belongs to Central Nervous System.
Why it happens
BCRP inhibition by lapatinib may increase systemic exposure to ozanimod active metabolites.
What to do
Monitor heart rate, liver tests and signs of infection. Consider an alternative if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Lapatinib with Ozanimod?
MediHelp rates the interaction as moderate. Lapatinib and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits BCRP and may raise exposure to ozanimod's active metabolites. This could increase ozanimod adverse effects such as bradycardia, hepatic effects and infection.
How serious is the interaction between Lapatinib and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, liver tests and signs of infection. Consider an alternative if adverse effects develop.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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