Drug interactions
Lapatinib + Palbociclib
Severity: Moderate
Lapatinib and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is a CYP3A4 inhibitor and may raise palbociclib exposure. This may increase neutropenia and other adverse effects.
What this interaction means in plain words
Lapatinib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Palbociclib belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4-mediated palbociclib metabolism.
What to do
Monitor complete blood counts frequently and reduce or interrupt palbociclib for neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Palbociclib
Frequently asked questions
Can I take Lapatinib with Palbociclib?
MediHelp rates the interaction as moderate. Lapatinib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib is a CYP3A4 inhibitor and may raise palbociclib exposure. This may increase neutropenia and other adverse effects.
How serious is the interaction between Lapatinib and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce or interrupt palbociclib for neutropenia.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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