Drug interactions
Lapatinib + Repotrectinib
Severity: Major
Lapatinib and Repotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is a CYP3A4 and P-gp inhibitor and may increase repotrectinib exposure. Higher levels could worsen neurologic effects such as dizziness and ataxia and other toxicities.
What this interaction means in plain words
Lapatinib and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lapatinib belongs to Oncology; Repotrectinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux of repotrectinib.
What to do
Avoid concomitant use where possible. If it cannot be avoided, monitor closely for repotrectinib adverse effects and reduce its dose per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Lapatinib with Repotrectinib?
MediHelp rates the interaction as major. Lapatinib and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lapatinib is a CYP3A4 and P-gp inhibitor and may increase repotrectinib exposure. Higher levels could worsen neurologic effects such as dizziness and ataxia and other toxicities.
How serious is the interaction between Lapatinib and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible. If it cannot be avoided, monitor closely for repotrectinib adverse effects and reduce its dose per labeling.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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