Drug interactions
Lapatinib + Ruxolitinib
Severity: Moderate
Lapatinib and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and may increase ruxolitinib exposure. This could worsen cytopenias such as thrombocytopenia and neutropenia.
What this interaction means in plain words
Lapatinib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Ruxolitinib belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4 metabolism of ruxolitinib.
What to do
Monitor blood counts more often and reduce the ruxolitinib dose if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Lapatinib with Ruxolitinib?
MediHelp rates the interaction as moderate. Lapatinib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and may increase ruxolitinib exposure. This could worsen cytopenias such as thrombocytopenia and neutropenia.
How serious is the interaction between Lapatinib and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts more often and reduce the ruxolitinib dose if cytopenias develop.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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