Drug interactions
Lapatinib + Sevoflurane
Severity: Moderate
Lapatinib and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval and sevoflurane may add to repolarization delay. Together they could raise the risk of ventricular arrhythmia.
What this interaction means in plain words
Lapatinib and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check the baseline ECG and correct potassium and magnesium. Monitor the ECG during and after anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Sevoflurane?
MediHelp rates the interaction as moderate. Lapatinib and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib can prolong the QT interval and sevoflurane may add to repolarization delay. Together they could raise the risk of ventricular arrhythmia.
How serious is the interaction between Lapatinib and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline ECG and correct potassium and magnesium. Monitor the ECG during and after anesthesia.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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