Drug interactions
Lapatinib + Stiripentol
Severity: Moderate
Lapatinib and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and also induces CYP3A4 and inhibits P-glycoprotein, so lapatinib exposure may change unpredictably. Increased exposure raises the risk of toxicity, while induction could reduce antitumor efficacy.
What this interaction means in plain words
Lapatinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol has mixed CYP3A4 inhibitory and inductive effects and inhibits P-gp, altering lapatinib disposition.
What to do
Monitor lapatinib tolerability (diarrhea, liver tests, QTc) and treatment response. Adjust the lapatinib dose if toxicity or loss of effect occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Lapatinib with Stiripentol?
MediHelp rates the interaction as moderate. Lapatinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and also induces CYP3A4 and inhibits P-glycoprotein, so lapatinib exposure may change unpredictably. Increased exposure raises the risk of toxicity, while induction could reduce antitumor efficacy.
How serious is the interaction between Lapatinib and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lapatinib tolerability (diarrhea, liver tests, QTc) and treatment response. Adjust the lapatinib dose if toxicity or loss of effect occurs.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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