Drug interactions
Lapatinib + Temsirolimus
Severity: Moderate
Lapatinib and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib may increase temsirolimus and sirolimus exposure through CYP3A4 inhibition. This could raise the risk of mucositis, cytopenias, hyperglycemia and pneumonitis.
What this interaction means in plain words
Lapatinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Temsirolimus belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4 metabolism of temsirolimus and its metabolite sirolimus.
What to do
Monitor blood counts, glucose and respiratory symptoms, and reduce temsirolimus dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Lapatinib with Temsirolimus?
MediHelp rates the interaction as moderate. Lapatinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib may increase temsirolimus and sirolimus exposure through CYP3A4 inhibition. This could raise the risk of mucositis, cytopenias, hyperglycemia and pneumonitis.
How serious is the interaction between Lapatinib and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, glucose and respiratory symptoms, and reduce temsirolimus dose if toxicity occurs.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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