Drug interactions
Lapatinib + Tiotropium-olodaterol
Severity: Moderate
Lapatinib and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval, and beta2-agonists such as olodaterol may add to this risk through hypokalemia and sympathetic stimulation. The combination may increase the chance of ventricular arrhythmias, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Lapatinib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lapatinib belongs to Oncology; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta2-agonist-induced hypokalemia and cardiac stimulation.
What to do
Correct potassium and magnesium before treatment and monitor them. Consider ECG monitoring in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Lapatinib with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Lapatinib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib can prolong the QT interval, and beta2-agonists such as olodaterol may add to this risk through hypokalemia and sympathetic stimulation. The combination may increase the chance of ventricular arrhythmias, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Lapatinib and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before treatment and monitor them. Consider ECG monitoring in patients with other QT risk factors.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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