Drug interactions
Larotrectinib + Progesterone
Severity: Minor
Larotrectinib and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a weak CYP3A4 inhibitor in vitro and could slightly raise progesterone exposure. Clinical relevance is probably minimal.
What this interaction means in plain words
Larotrectinib and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Progesterone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 inhibition reducing progesterone metabolism.
What to do
No dose change is usually required; monitor for progestogenic adverse effects such as drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Progesterone?
MediHelp rates the interaction as minor. Larotrectinib and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a weak CYP3A4 inhibitor in vitro and could slightly raise progesterone exposure. Clinical relevance is probably minimal.
How serious is the interaction between Larotrectinib and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor for progestogenic adverse effects such as drowsiness.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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