Drug interactions
Larotrectinib + Ticlopidine
Severity: Minor
Larotrectinib and Ticlopidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak inhibitor of CYP3A4 in vitro, so it could slightly increase ticlopidine exposure. The clinical significance is likely small and has not been well studied.
What this interaction means in plain words
Larotrectinib and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Ticlopidine belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing ticlopidine metabolism.
What to do
No dose change is usually needed; continue routine blood count monitoring for ticlopidine and watch for bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticlopidine
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Ticlopidine?
MediHelp rates the interaction as minor. Larotrectinib and Ticlopidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak inhibitor of CYP3A4 in vitro, so it could slightly increase ticlopidine exposure. The clinical significance is likely small and has not been well studied.
How serious is the interaction between Larotrectinib and Ticlopidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; continue routine blood count monitoring for ticlopidine and watch for bleeding.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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