Drug interactions
Larotrectinib + Vilazodone
Severity: Minor
Larotrectinib and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and in vitro data suggest it can inhibit CYP3A4, so vilazodone exposure might rise slightly. The clinical significance is unknown and is expected to be small.
What this interaction means in plain words
Larotrectinib and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Larotrectinib belongs to Oncology; Vilazodone belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing vilazodone clearance; not well established clinically.
What to do
No preemptive dose change is needed; watch for increased vilazodone adverse effects and adjust the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Larotrectinib with Vilazodone?
MediHelp rates the interaction as minor. Larotrectinib and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and in vitro data suggest it can inhibit CYP3A4, so vilazodone exposure might rise slightly. The clinical significance is unknown and is expected to be small.
How serious is the interaction between Larotrectinib and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No preemptive dose change is needed; watch for increased vilazodone adverse effects and adjust the dose if they occur.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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