Drug interactions
Lasmiditan + Loperamide
Severity: Moderate
Lasmiditan and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-glycoprotein and may increase absorption and systemic exposure of loperamide, a P-gp substrate. Higher exposure raises the risk of central opioid effects and cardiac toxicity, though the effect is likely modest at standard doses.
What this interaction means in plain words
Lasmiditan and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Inhibition of P-glycoprotein efflux by lasmiditan increases loperamide absorption and CNS and systemic penetration.
What to do
Use loperamide at the lowest effective dose and avoid exceeding labeled limits. Monitor for excessive sedation, dizziness, constipation or palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Loperamide?
MediHelp rates the interaction as moderate. Lasmiditan and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits intestinal P-glycoprotein and may increase absorption and systemic exposure of loperamide, a P-gp substrate. Higher exposure raises the risk of central opioid effects and cardiac toxicity, though the effect is likely modest at standard doses.
How serious is the interaction between Lasmiditan and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use loperamide at the lowest effective dose and avoid exceeding labeled limits. Monitor for excessive sedation, dizziness, constipation or palpitations.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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