Drug interactions
Lasmiditan + Lovastatin
Severity: Minor
Lasmiditan and Lovastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-glycoprotein and may raise exposure to P-gp substrates. Lovastatin is not a major P-gp-dependent drug, so the effect is likely small, but higher statin levels could increase the risk of myopathy.
What this interaction means in plain words
Lasmiditan and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Lovastatin belongs to Cardiovascular.
Why it happens
Lasmiditan inhibits P-glycoprotein efflux, which may modestly increase lovastatin absorption.
What to do
No routine change is needed. Counsel the patient to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Lovastatin?
MediHelp rates the interaction as minor. Lasmiditan and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits intestinal P-glycoprotein and may raise exposure to P-gp substrates. Lovastatin is not a major P-gp-dependent drug, so the effect is likely small, but higher statin levels could increase the risk of myopathy.
How serious is the interaction between Lasmiditan and Lovastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Counsel the patient to report unexplained muscle pain or weakness.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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