Drug interactions
Lasmiditan + Meperidine
Severity: Moderate
Lasmiditan and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and somnolence, and concurrent opioids may intensify CNS depression and impair psychomotor function. Lasmiditan also has serotonergic receptor activity, though serotonin syndrome has not been clearly established.
What this interaction means in plain words
Lasmiditan and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; lasmiditan is a selective 5-HT1F agonist.
What to do
Monitor for excessive sedation and counsel patients not to drive for at least 8 hours after a lasmiditan dose. Reduce the opioid dose if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Meperidine?
MediHelp rates the interaction as moderate. Lasmiditan and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and somnolence, and concurrent opioids may intensify CNS depression and impair psychomotor function. Lasmiditan also has serotonergic receptor activity, though serotonin syndrome has not been clearly established.
How serious is the interaction between Lasmiditan and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel patients not to drive for at least 8 hours after a lasmiditan dose. Reduce the opioid dose if sedation is excessive.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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