Drug interactions
Lasmiditan + Nitrofurantoin
Severity: Minor
Lasmiditan and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits BCRP in vitro, and nitrofurantoin is a possible BCRP substrate. Systemic exposure of nitrofurantoin might rise, but clinical significance is unproven.
What this interaction means in plain words
Lasmiditan and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
In vitro BCRP inhibition by lasmiditan could reduce efflux of nitrofurantoin.
What to do
No routine change is needed for short courses. Monitor for nitrofurantoin adverse effects if used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Nitrofurantoin?
MediHelp rates the interaction as minor. Lasmiditan and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits BCRP in vitro, and nitrofurantoin is a possible BCRP substrate. Systemic exposure of nitrofurantoin might rise, but clinical significance is unproven.
How serious is the interaction between Lasmiditan and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for short courses. Monitor for nitrofurantoin adverse effects if used together.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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