Drug interactions
Lasmiditan + Paliperidone
Severity: Minor
Lasmiditan and Paliperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-glycoprotein in vitro, and paliperidone is a P-gp substrate, so paliperidone exposure could rise. The clinical significance is uncertain and likely modest.
What this interaction means in plain words
Lasmiditan and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Possible inhibition of P-glycoprotein efflux by lasmiditan, increasing paliperidone absorption.
What to do
No routine change is needed. Monitor for increased paliperidone adverse effects such as sedation, orthostasis or extrapyramidal symptoms after lasmiditan use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Paliperidone?
MediHelp rates the interaction as minor. Lasmiditan and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits intestinal P-glycoprotein in vitro, and paliperidone is a P-gp substrate, so paliperidone exposure could rise. The clinical significance is uncertain and likely modest.
How serious is the interaction between Lasmiditan and Paliperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for increased paliperidone adverse effects such as sedation, orthostasis or extrapyramidal symptoms after lasmiditan use.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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