Drug interactions
Lasmiditan + Pravastatin
Severity: Minor
Lasmiditan and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-gp in vitro and may increase exposure to P-gp substrates. Pravastatin is only a minor P-gp substrate, so the clinical effect is expected to be small.
What this interaction means in plain words
Lasmiditan and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Pravastatin belongs to Cardiovascular.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by lasmiditan may modestly increase pravastatin absorption.
What to do
No routine adjustment needed; counsel patients to report muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Pravastatin?
MediHelp rates the interaction as minor. Lasmiditan and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-gp in vitro and may increase exposure to P-gp substrates. Pravastatin is only a minor P-gp substrate, so the clinical effect is expected to be small.
How serious is the interaction between Lasmiditan and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; counsel patients to report muscle symptoms.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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