Drug interactions
Lasmiditan + Rimegepant
Severity: Minor
Lasmiditan and Rimegepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and may raise rimegepant exposure. The clinical effect is uncertain and probably small, though both drugs are used for migraine.
What this interaction means in plain words
Lasmiditan and Rimegepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Rimegepant belongs to Central Nervous System.
Why it happens
Possible inhibition of intestinal P-glycoprotein efflux of rimegepant.
What to do
Avoid repeat rimegepant doses within 48 hours and monitor for additive adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rimegepant
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Rimegepant?
MediHelp rates the interaction as minor. Lasmiditan and Rimegepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-glycoprotein in vitro and may raise rimegepant exposure. The clinical effect is uncertain and probably small, though both drugs are used for migraine.
How serious is the interaction between Lasmiditan and Rimegepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid repeat rimegepant doses within 48 hours and monitor for additive adverse effects.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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