Drug interactions
Lasmiditan + Rosuvastatin
Severity: Moderate
Lasmiditan and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits BCRP in vitro and may raise rosuvastatin levels. Clinical relevance is uncertain but increased statin effects are possible.
What this interaction means in plain words
Lasmiditan and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Rosuvastatin belongs to Cardiovascular.
Why it happens
Inhibition of intestinal BCRP efflux increases rosuvastatin absorption.
What to do
Monitor for muscle symptoms. Consider a lower rosuvastatin dose if intake of lasmiditan is frequent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Rosuvastatin?
MediHelp rates the interaction as moderate. Lasmiditan and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits BCRP in vitro and may raise rosuvastatin levels. Clinical relevance is uncertain but increased statin effects are possible.
How serious is the interaction between Lasmiditan and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms. Consider a lower rosuvastatin dose if intake of lasmiditan is frequent.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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