Drug interactions
Lasmiditan + Saxagliptin
Severity: Minor
Lasmiditan and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-glycoprotein, which may increase absorption of P-gp substrates. Saxagliptin is only a modest P-gp substrate, so any increase is likely small and brief with occasional migraine dosing.
What this interaction means in plain words
Lasmiditan and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lasmiditan belongs to Central Nervous System; Saxagliptin belongs to Endocrine.
Why it happens
Inhibition of P-gp efflux by lasmiditan may raise saxagliptin bioavailability.
What to do
No dose change is usually needed. Be aware of the interaction and watch for hypoglycemia if lasmiditan is used often.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Saxagliptin?
MediHelp rates the interaction as minor. Lasmiditan and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits intestinal P-glycoprotein, which may increase absorption of P-gp substrates. Saxagliptin is only a modest P-gp substrate, so any increase is likely small and brief with occasional migraine dosing.
How serious is the interaction between Lasmiditan and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Be aware of the interaction and watch for hypoglycemia if lasmiditan is used often.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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