Drug interactions
Lasmiditan + Sirolimus
Severity: Moderate
Lasmiditan and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and may increase sirolimus exposure. Clinical data are limited, and exposure to lasmiditan is intermittent.
What this interaction means in plain words
Lasmiditan and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lasmiditan belongs to Central Nervous System; Sirolimus belongs to Miscellaneous.
Why it happens
Inhibition of intestinal P-glycoprotein efflux of sirolimus.
What to do
Where feasible use another acute migraine treatment, or avoid lasmiditan on days of sirolimus dosing. Monitor for sirolimus toxicity and check trough levels if use is frequent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Lasmiditan with Sirolimus?
MediHelp rates the interaction as moderate. Lasmiditan and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein in vitro and may increase sirolimus exposure. Clinical data are limited, and exposure to lasmiditan is intermittent.
How serious is the interaction between Lasmiditan and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible use another acute migraine treatment, or avoid lasmiditan on days of sirolimus dosing. Monitor for sirolimus toxicity and check trough levels if use is frequent.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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